We are looking for several highly motivated (Sr) Research Associates/ (Senior) Scientists responsible to support one of Ridgeline Discovery’s portfolio company about to come out of stealth mode.
The successful candidate will have experience in High throughput screening and/or Mass Spectrometry-Based Drug Discovery ideally applied to targeted protein degradation (job title will be based on previous experience). She/he will be a highly motivated and enthusiastic team player with proven organizational skills, and a strong scientific background to impact early and late-stage development projects.
(Senior) Research Associate/(Senior) Scientist, High throughput Proteomics in Targeted Protein Degradation
Basel, CH, Tech Park HB-C
Full-time
Permanent employee
About us
Responsibilities
- Collaborate with cell biologists to prepare samples for MS-based screening, operate state-of-the-art high resolution mass spectrometers, analyze and interpret multi-layered data, and present findings to stakeholders and external collaborators.
- Develop and implement sample preparation and automation protocols, optimize mass spectrometer performance, and adapt novel technologies.
- Oversee data generation and analysis of large-scale proteomics datasets.
- Work closely with an interdisciplinary team to identify potential novel drug targets.
- Stay engaged with scientific literature to remain up-to-date with the latest developments and novel approaches.
- Be proactive and open-minded in contributing to the achievement of the company’s goals in a dynamic and fast-paced start-up environment.
- Characterize novel drug targets and their mechanisms of action.
- Contribute to laboratory general organization and maintenance, manage laboratory stocks and ordering.
- Ensure compliance with good laboratory practices including safety regulations, data management, data recording in electronic notebooks and archiving.
Qualifications
- Research associate level: you hold a Master, Bachelor degree or laboratory apprenticeship (or equivalent) in Biotechnology, Biochemistry, Molecular Biology, with at least 2 years of experience in academia, contract research, or the biotechnology/pharmaceutical industry, particularly in the field of proteomics.
- Scientist level: you hold a PhD in Biochemistry, Biology, Chemical Biology or other relevant disciplines and preferentially 2+ years’ relevant MS experience in drug discovery in the pharmaceutical, biotech or MS contract research setting.
- You are skilled in designing, planning, and executing laboratory experiments and are passionate about analyzing data and sharing your findings.
- Experience with the latest generation UHPLC systems and mass spectrometers (such as Orbitrap Astral or timsTOF) for in-depth proteome characterization and/or targeted analysis is a plus.
- Experience in high-throughput peptide/protein sample preparation (S-trap/SP3/PAC), automation (Tecan/Biomek/Hamilton/Agilent Bravo/OT-2) and DIA (data-independent acquisition) data analysis is desired.
- Knowledge of Spectronaut or DIA-NN and bioinformatics tools, such as R or Python, is a plus.
- You are an organized team player, adept at critical thinking and problem solving, with excellent communication skills in English.
- Must be highly independent, able to work well in a highly collaborative team-oriented environment. Capable of thriving and multi-tasking in a fast-paced “start-up” environment.
- Self-motivated, willingness to learn, strong work ethic, attention to detail, organizational skills, and excellent communication skills are required for this position.
- Fluency in English required
What we currently offer
- Prime Location: Our state-of-the-art laboratories and modern offices are located at the Technologiepark Basel, one of the city’s leading hubs for innovative and ambitious life-science start-ups.
- Commuter Benefits: We support your individual commuting needs with flexible options, including parking facilities or a commuter contribution.
- Flexible Working: We believe in flexibility and support modern ways of working wherever the role and business needs allow.
- Christmas Closure: Enjoy a well-deserved break at the end of the year. In addition to 24 days of annual leave, our offices and laboratories are closed between Christmas and New Year.
- Birthday Day Off: Your birthday is your day. Celebrate it your way with an extra paid day off to enjoy the things that matter to you.
- Lunch & Food: Great ideas often start around the lunch table. Enjoy delicious meals with your colleagues, supported through our Lunch Check benefit.
- Coffee & Connection: Take a break, grab a complimentary coffee, and connect with colleagues throughout the day.
- Learning & Development: We invest in our people and support individual growth, learning and professional development.
- Innovation & Creativity: Be part of an innovative, entrepreneurial and creative environment where new ideas are encouraged and collaboration is at the heart of what we do.
- Our People: Join an international and diverse team of talented, curious and passionate people who are united by the ambition to make a difference in science and healthcare.
Über uns
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